Preparing for NEET MDS? You already know the syllabus — the real challenge is applying it under exam pressure. These 10 sample questions mirror the actual distribution across Anatomy, Physiology, Biochemistry, Pathology, Microbiology, Pharmacology, Dental Anatomy, Oral Pathology, and Clinical Dentistry. Each solution shows the reasoning, not just the correct option, so you can spot patterns and avoid common traps.
How to use these questions
- Attempt each question on your own before reading the solution.
- Time yourself — aim for 60–90 seconds per question.
- Note the topics where you hesitate; that’s your revision list.
Section 1: Anatomy
Q1. Which of the following structures passes through the parotid gland?
A) Facial nerve B) Mandibular nerve C) Maxillary artery D) Lingual nerve
Solution: The parotid gland is traversed by the facial nerve (CN VII), the retromandibular vein, and the external carotid artery. The mandibular nerve (V3) and lingual nerve are not within the gland. Answer: A)
Section 2: Physiology
Q2. Which of the following is the primary determinant of the resting membrane potential?
A) Sodium-potassium ATPase activity B) Potassium permeability C) Sodium permeability D) Chloride permeability
Solution: At rest, the membrane is most permeable to potassium (K+), so the equilibrium potential for K+ dominates. The Na+/K+ ATPase maintains the gradients but does not set the potential directly. Answer: B)
Section 3: Biochemistry
Q3. Which enzyme is deficient in Lesch-Nyhan syndrome?
A) Adenosine deaminase B) Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) C) Xanthine oxidase D) Orotate phosphoribosyltransferase
Solution: Lesch-Nyhan syndrome is an X-linked disorder caused by deficiency of HGPRT, leading to uric acid overproduction and neurological symptoms. Answer: B)
Section 4: Pathology
Q4. A 45-year-old male presents with a painless, firm, mobile lymph node. Biopsy shows Reed-Sternberg cells. What is the most likely diagnosis?
A) Non-Hodgkin lymphoma B) Hodgkin lymphoma C) Tuberculous lymphadenitis D) Metastatic carcinoma
Solution: Reed-Sternberg cells are the hallmark of Hodgkin lymphoma. Their presence, along with the clinical picture, clinches the diagnosis. Answer: B)
Section 5: Microbiology
Q5. Which organism is the most common cause of bacterial meningitis in neonates?
A) Streptococcus pneumoniae B) Neisseria meningitidis C) Group B Streptococcus (Streptococcus agalactiae) D) Haemophilus influenzae type b
Solution: In neonates, Group B Streptococcus is the leading cause of bacterial meningitis. S. pneumoniae and N. meningitidis are more common in older children and adults. Answer: C)
Section 6: Pharmacology
Q6. Which of the following drugs is a direct-acting cholinergic agonist?
A) Neostigmine B) Pilocarpine C) Atropine D) Physostigmine
Solution: Pilocarpine directly stimulates muscarinic receptors. Neostigmine and physostigmine are cholinesterase inhibitors; atropine is an antagonist. Answer: B)
Section 7: Dental Anatomy
Q7. Which tooth has the longest root in the permanent dentition?
A) Maxillary canine B) Mandibular canine C) Maxillary incisor D) Mandibular molar
Solution: The maxillary canine typically has the longest root of all permanent teeth, providing excellent anchorage. Answer: A)
Section 8: Oral Pathology
Q8. A painless, slow-growing swelling of the mandible shows a multilocular radiolucency on X-ray. Histology shows fibrous stroma with strands of odontogenic epithelium. What is the most likely diagnosis?
A) Ameloblastoma B) Odontogenic keratocyst C) Dentigerous cyst D) Central giant cell granuloma
Solution: The combination of multilocular radiolucency, fibrous stroma, and odontogenic epithelial strands is classic for ameloblastoma. Answer: A)
Section 9: Conservative Dentistry & Endodontics
Q9. Which instrument is used to determine the working length in root canal treatment?
A) Barbed broach B) K-file C) Gates-Glidden drill D) Lentulo spiral
Solution: A K-file is inserted into the canal and radiographically verified to determine working length. Barbed broaches are for pulp extirpation; Gates-Glidden drills enlarge the canal; Lentulo spirals carry sealer. Answer: B)
Section 10: Oral Surgery
Q10. Which nerve is most commonly injured during extraction of a mandibular third molar?
A) Lingual nerve B) Inferior alveolar nerve C) Buccal nerve D) Mental nerve
Solution: The inferior alveolar nerve lies close to the roots of the mandibular third molar and is the most frequently injured during its extraction, leading to temporary or permanent paresthesia of the lower lip and chin. Answer: B)
Take a free NEET MDS demo mock to find out where you stand: Try the demo →
Why these questions matter
These questions represent the core concepts that appear repeatedly in NEET MDS. The exam tests not just recall but the ability to apply knowledge to clinical scenarios. In the actual exam, you will face 240 questions across three sections — General Medicine, Surgery, and Clinical Dentistry — with a negative marking of 1/3 for each wrong answer.
Common mistakes to avoid:
- Overthinking — many questions have one clearly best answer.
- Ignoring negative marking — guess only when you can eliminate two options.
- Spending too long on a single question — mark and move on.
How to build your NEET MDS strategy
- 1Master the high-yield topics — Anatomy, Pathology, and Pharmacology account for a large chunk of the paper.
- 2Practice with timed mocks — Simulate the real exam environment to build speed and accuracy.
- 3Review every solution — Even for correct answers, read the explanation to reinforce the concept.
See NEET MDS mock-test packs and pricing: View plans →
Final tips for exam day
- Reach the centre early and carry your admit card and ID.
- Read each question carefully — watch for "except" or "not".
- Manage your time: roughly 1 minute per question is a good pace.
- Stay calm — a clear head beats last-minute cramming.